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Pathophysiology. p57 is a cyclin dependent kinase inhibitor protein, the product of the paternally imprinted, maternally expressed gene CDKN1C (p57KIP2) located on chromosome 11p15.5 (Lab Invest 1998;78:269) Maternal genetic material and intact genomic imprinting is essential for p57 protein expression. Gestations containing maternal genetic ...
13 sept. 2021 · Synovial sarcoma, monophasic, FNCLCC grade 2 (see comment) Comment: The tumor is composed of fascicles of bland spindle cells with sparse cytoplasm and relatively uniform, ovoid hyperchromatic nuclei and inconspicuous nucleoli. The stroma contains strands of wiry collagen. Mitoses are sparse (2 mitoses/10 high power fields).
Essential features. Hydatidiform mole resulting from fertilization of a normal egg by 2 spermatozoa or by 1 spermatozoa followed by duplication of the paternal chromosomal content. 2 discrete populations of villi (enlarged, hydropic villi and small, fibrotic villi), with the larger villi showing irregular scalloped borders and cistern formation.
Common antibody for identifying T cells. Pathophysiology. CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction (Immunity 2006;24:133, Nature 2019;573:546)
30 juil. 2021 · ICD-O: 9044/3 - clear cell sarcoma, NOS (except of kidney M-8964/3) ICD-10: C49.9 - malignant neoplasm of connective and soft tissue, unspecified. ICD-11: 2B5K & XH77N6 - unspecified malignant soft tissue tumors or sarcomas of bone or articular cartilage of other or unspecified sites & clear cell sarcoma of soft tissue.
7 nov. 2023 · T cells positive for follicular helper T cell markers (e.g., CD4+, CD57+, PD-1+, ICOS+, CXCL13+, MUM1+, BCL6+, BOB1+), which form rosette-like structures around the neoplastic B cells favors NLPHL over THRLBCL Presence of expanded follicular dendritic cell meshwork positive for CD21, CD23 and CD35 favors NLPHL over THRLBCL (Pathology 2020;52:142)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired somatic mutation in the X linked phosphatidylinositol glycan class A (PIGA) gene, which leaves hematopoietic cells unable to produce the glycosylphosphatidylinositol (GPI) anchor that links cell surface proteins to the plasma membrane (Hematol Transfus Cell Ther 2020 Jul 6 [Epub ahead of print], Blood 2014;124:2804)
Epidemiology. MPNST can occur in the following settings: Sporadic (approximately 50%) In neurofibromatosis type 1 (40 - 50%) In the setting of prior radiation therapy (10%) Plexiform neurofibroma is a common precursor lesion in patients with NF1. Patients with NF1 have an 8 - 13% lifetime risk of developing MPNST.
Nephrogenic metaplasia involves benign localized or diffuse, benign papillary, tubular or cystic metaplastic changes of the urothelium in response to chronic infection, calculi, injury or prolonged catheterization
4 août 2015 · Bei mir war der CD57 zu Beginn der Therapien extrem gering (5 bei unterem Normwert 60) und ist jetzt bei 41 (bei unterem Normwert 18). Ich weiß nicht, ob das jetzt von einem anderen Labor kommt oder der untere Normwert geändert wurde. Der jetzige Wert bezieht sich auf die CD57-positiven NK-Zellen, beim alten Wert stand nur CD57.
