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Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1). The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite
Cutaneous anthrax is rarely fatal if treated, because the infection area is limited to the skin, preventing the lethal factor, edema factor, and protective antigen from entering and destroying a vital organ. Without treatment, up to 20% of cutaneous skin infection cases progress to toxemia and death.
15 déc. 2004 · L'anthrax est une zoonose (maladie animale contagieuse) touchant principalement les mammifères. Bien que rare et sporadique dans la plupart des pays industrialisés, elle représente un problème de santé publique mais aussi un problème économique dans les pays en voie de développement.
7 sept. 2020 · Cellular targets of anthrax lethal factor are identified to reveal the molecular basis of toxin-induced death.
- Megan A. Mendenhall, Shihui Liu, Makayla K. Portley, Danielle O’Mard, Rasem Fattah, Roman Szabo, Tho...
- 2020
The exotoxins secreted by B. anthracis use CMG2 as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease. This review focuses on the activities of anthrax toxins and their roles in initial and late stages of anthrax infection.
- Shihui Liu, Mahtab Moayeri, Stephen H. Leppla
- 10.1016/j.tim.2014.02.012
- 2014
- 2014/06
22 juin 2021 · Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or...
10 mars 2016 · Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic acid capsule and the tripartite anthrax toxin.
- www.creativebiolabs.net/antibodies
AnnonceAnti-Anthrax lethal factor - Anthrax lethal factor Antibody
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