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In 2310, a new sport, Gene-Fusion, is all the rage. In this exciting game, specially-trained athletes, called Fusers, design their own super-creature by combining three forms of animal DNA. It is ...
A gene fusion is a hybrid gene formed from two previously independent genes. It can occur as a result of translocation, interstitial deletion, or chromosomal inversion. Many gene fusion mutations are highly characterized and are a major cause of cancer, making accurate detection critical to research and to clinical applications.
In the year 2310, a new sport, GENE-FUSION is all the rage! In this exciting game, specially-trainer athletes, called Fusers, design their own super-creature by combining three forms of animal DNA... Four teens, seemingly plucked from obscurity, are trained to be Fusers. They become instant celebrities they perform before sold out crowds. But what hey don't know is that each of them has a role ...
8 mai 2022 · Family-inherited fusion genes have been known to be associated with human disease for decades. However, only a small number of them have been discovered so far. In this report, monozygotic (MZ) twins are used as a genetic model to investigate hereditary fusion genes (HFG). We have analyzed RNA-Seq from 37 MZ twins and discovered 1,180 HFGs, the maximum of which is 608 per haploid genome. Eight ...
27 févr. 2024 · Abstract. The fusion genes NRG1 and NRG2 , members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, NRG1 retains its EGF-like active domain, binds to the ERBB ligand family, and triggers intracellular signaling cascades, promoting uncontrolled cell proliferation.
Gene fusions are the traditional genetic tool for studying regulation. The most popular approach is to construct a hybrid gene (gene fusion) using a truncated lacZ gene that contains the coding sequence for the β-galactosidase enzyme but lacks signals for initiating transcription and sometimes also lacks its translational start signals.
