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A.B. 1976, University of California, BerkeleyPh.D. 1981, Stanford UniversityOverview
Technology development lies at the heart of the Smith Lab. We endeavor to anticipate and then create the new analytical tools needed by the biological researchers of tomorrow. Throughout our history, from DNA sequencing to advanced proteomics, we are always pushing the cutting edge. Our credo is to turn science fiction into science. Imagine something important that cannot yet be done, conceive of how to do it, and make it happen. We apply a broad array of techniques to solve many challenges i...
Biological Mass Spectrometry
Mass spectrometry is a core technology for many of the group’s projects. We have interest in developing new methods for preparing, fractionating, separating, and introducing samples into the mass spectrometer, to improve sensitivity for the most challenging analytical problems. We are creating new software control methods to improve the efficiency of the mass spectrometer operation and to improve proteomic coverage. We place a great emphasis on data analysis. We have developed robust software...
Proteoforms and the Proteoform Pipeline
Our group introduced the concept of the proteoform to the proteomics community. The proteoform is a specific form of a protein with its posttranslational modifications. The proteoform is the actual biological actor in complex systems. Each distinct proteoform can have a unique biological function. There are several thousand different proteoforms in a typical complex biological sample. Identifying all of them presents one of the most difficult current challenges for proteomics. The fields very...
Bioinformatics and Data Mining
The data analysis phase of our mass spectrometry work looks at every aspect of the proteome. We have developed proteogenomic tools to reveal protein sequence alterations unique to the organism, including unknown amino acid substitutions and splice variants. We have tools to reveal a broad spectrum of unknown PTMs including glycosylations. And we have tools for quantitative data analysis and visualization. We are interested in all aspects of biological big data with an emphasis on improving th...
Lloyd M. Smith (born October 3, 1954) is a professor of chemistry and the founder of Third Wave Technologies. Early life. Smith spent his formative years in Berkeley, California, where his parents worked as professors of physics and mathematics.
Lloyd M Smith. Professor of Chemistry, University of Wisconsin. Verified email at chem.wisc.edu - Homepage. bioanalytical chemistry. Title. Sort. Sort by citations Sort by year Sort by title....
3,669 Followers, 1,646 Following, 58 Posts - Harriet Lloyd-Smith (@harriart__) on Instagram: "Art, music, etc. @plastermagazine Once @wallpapermag, @elephantmagazine Also painting maker".
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Oral history interview with Lloyd M. Smith. 2008-Mar-02. Lloyd M. Smith grew up in Berkeley, California, one of four children. His father was a physicist at Lawrence Berkeley National Laboratory and his mother a professor of mathematics.
The Smith Group is an interdisciplinary group of researchers engaged in executing important, interesting, and impactful science with fun people. The driving focus of the lab is the development of new mass spectrometric technologies for the comprehensive identification and quantification of proteoforms in complex systems.
