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Receptor, trkA. Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the fir ….
30 août 2019 · Gene fusions are appreciated as ideal cancer biomarkers and therapeutic targets. Chimeric RNAs are traditionally thought to be products of gene fusions, and thus, also cancer-specific. Recent research has demonstrated that chimeric RNAs can be generated by intergenic splicing in the absence of gene fusion, and such chimeric RNAs are also found ...
28 févr. 2022 · Gene fusions can play important roles in tumor initiation and progression. While fusion detection so far has been from bulk samples, full-length single-cell RNA sequencing (scRNA-seq) offers the ...
20 juil. 2021 · The neurotrophic tyrosine receptor kinase (NTRK) genes 1/2/3 encode tropomyosin receptor kinases (TRK) A/B/C respectively.Inter-chromosomal rearrangements causing NTRK gene fusions can result in ...
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8 oct. 2013 · Abstract. Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas ...
31 mars 2022 · To detect gene fusions, Caris performs MI Transcriptome testing which covers 22,000 genes and has the ability to even detect the rarest fusion events. MI Tr...
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