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28 nov. 2023 · The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches.
The BLAST programs achieve much of their speed by avoiding the calculation of optimal alignment scores for all but a handful of unrelated sequences. The must therefore rely upon a pre-estimation of the parameters lambda and K, for a selected set of substitution matrices and gap costs.
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In bioinformatics, BLAST (basic local alignment search tool) is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences.
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14 juil. 2011 · blast Basic Local Alignment Search Tool ( Altschul et al., 1990 & 1997 ) is a sequence comparison algorithm optimized for speed used to search sequence databases for optimal local alignments to a query .
