Résultats de recherche
Il y a 4 jours · We leveraged three RegulomeDB-derived functional regulatory annotations—SURF, TURF, and TLand—to construct polygenic risk models across a set of quantitative and binary traits highlighting functional mutations tagged by trait-associated tissue annotations.
- Spermatogenic cell-specific type 1 hexokinase (HK1S) is ...
We found that Hk1s was highly expressed and Hk2 was...
- Polygenic selection to a changing optimum under self ...
Detecting where selection acts in the genome, along with the...
- Genome-wide analysis of transcription-coupled repair reveals ...
Short-capped RNA-seq indicates shorter transcripts,...
- Spermatogenic cell-specific type 1 hexokinase (HK1S) is ...
29 juil. 2024 · We found that Hk1s was highly expressed and Hk2 was moderately expressed in sperm, while Hk1, Hk3, Gck and Hkdc1 were undetectable in sperm ( Fig 1A ). We then analyzed Hk1s mRNA transcript levels in various adult mouse tissues and found that Hk1s was restricted to the testis ( Fig 1B ).
17 juil. 2024 · Detecting where selection acts in the genome, along with the mechanisms at play, is a major research goal in evolutionary genetics. Many traits that affect fitness are complex and polygenic, meaning they are affected by multiple variants present genome–wide [ 1 ].
19 juil. 2024 · Short-capped RNA-seq indicates shorter transcripts, corresponding to transcription initiation events and enhancers shorter than 100 base pairs. In contrast, long-capped RNA-seq captures longer transcripts within the nucleus, encompassing both pre-mature and mature RNAs.
29 juil. 2024 · We found that Hk1s was highly expressed and Hk2 was moderately expressed in sperm, while Hk1, Hk3, Gck and Hkdc1 were undetectable in sperm (Fig 1A). We then analyzed Hk1s mRNA transcript lev-els in various adult mouse tissues and found that Hk1s was restricted to the testis (Fig 1B).
1 août 2024 · Polygenic risk scores (PRS) are instrumental in genetics, offering insights into an individual level genetic risk to a range of diseases based on accumulated genetic variations. These scores rely on Genome-Wide Association Studies (GWAS). However, precision in PRS is often challenged by the requirement of extensive sample sizes and the potential for overlapping datasets that can inflate PRS ...
18 juil. 2024 · Long-read sequencing is driving rapid progress in genome assembly across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost-effective hybrid Oxford Nanopore (ONT) long-read and Illumina short-read sequencing approach ...
