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7 avr. 2024 · Carbone Scol'ERE 2023-2024. Cette année, le CRE Lanaudière accompagnera 47 classes pour un total de 940 élèves de 4e, 5e et 6e année du primaire provenant de 14 écoles de la région dans le cadre du programme éducatif Carbone Scol’ERE. Pour plus de détails, consultez le communiqué de presse.
5 juil. 2011 · The c-Rel transcription factor is a unique member of the vertebrate nuclear factor κB (NF-κB) family, primarily because of its pervasive and specific role in mammalian B and T cell differentiation and function, as well as in human disease. As such, c-Rel is of interest to many researchers and clinicians studying mammalian immunology and human ...
7 mai 2021 · However, compared to cRel +/+ controls, the cRel +/– and cRel –/– pre-Treg TCR repertoires showed greater overlap with the published CD4 + Tcon TCR dataset (Fig. 2D). Thus, the changes in Nur77(GFP) levels, the hydrophobic index and TCR sharing caused by c-Rel deficiency converge on the pre-Treg stage, whereas these abnormalities were not detected in the thymic Treg population.
18 mai 2020 · Li et al. report that c-Rel, a member of the NF-κB transcription factor family, acts as a checkpoint for antitumor immunity as it promotes the generation of myeloid-derived suppressor cells and ...
28 juil. 2020 · cRel expression was elevated in murine lung and skin fibrosis models. Rel −/− mice were protected from developing pulmonary fibrosis. Soluble collagen production was significantly decreased in fibroblasts lacking cRel while proliferation and migration of these cells was significantly increased. cRel regulates genes involved in extracellular structure and matrix organization.
Moreover, c-Rel is shown to regulate Foxp3 transcription directly by binding to cis-regulatory elements at the Foxp3 locus upon TCR/CD28 stimulation, including the promoter and the newly identified conserved non-coding DNA sequence harboring a "permissive" chromatin status in Treg precursors. These findings collectively suggest that c-Rel may ...
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